Search results for "Acute tubular necrosis"

showing 5 items of 5 documents

Acute renal failure and liver dysfunction after subcutaneous injection of 3-sn-phosphatidylcholine (Lipostabil®)-case report.

2011

INTRODUCTION Drug-induced tubulointerstitial nephritis and acute tubular necrosis are common, and are often caused by drugs especially antibiotics or non-steroidal anti-inflammatory drugs. Drug-induced liver dysfunction and renal failure after subcutaneous injection of phosphatidylcholine was not reported so far. 3-sn-Phosphatidylcholine has been described as a cell lysis reaction-inducing drug. Its in vitro data indicated a relevant toxicity potential. In particular human cell types such as fibroblast-like preadipocytes, vascular and skeletal muscle cells, or renal epithelial cells react more sensitive than other human cell types. CASE REPORT We present a 28-year-old woman who received 3.5…

DrugAdultmedicine.medical_specialtymedicine.drug_classNauseamedia_common.quotation_subjectInjections SubcutaneousAntibioticsUrologyRenal functionSubcutaneous injectionmedicineHumansFat embolismAcute tubular necrosismedia_commonNephritisbusiness.industryGastroenterologyAcute Kidney Injurymedicine.diseaseSurgeryToxicityPhosphatidylcholinesFemalemedicine.symptombusinessZeitschrift fur Gastroenterologie
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Predicting patient outcome from acute renal failure comparing three general severity of illness scoring systems

2000

Predicting patient outcome from acute renal failure comparing three general severity of illness scoring systems.BackgroundA major problem of studies on acute renal failure (ARF) arises from a lack of prognostic tools able to express the medical complexity of the syndrome adequately and to predict patient outcome accurately. Our study was thus aimed at evaluating the predictive ability of three general prognostic models [version II of the Acute Physiology and Chronic Health Evaluation (APACHE II), version II of the Simplified Acute Physiology Score (SAPS II), and version II of the Mortality Probability Model at 24 hours (MPM24 II)] in a prospective, single-center cohort of patients with ARF …

Malemedicine.medical_specialtymedicine.medical_treatmentscoring systemsRisk AssessmentInterquartile rangePredictive Value of TestsInternal medicineSeverity of illnessOutcome Assessment Health CaremedicineHumansseverity of illness indexProspective StudiesSimplified Acute Physiology ScoreProspective cohort studymortality predictionAPACHEAgedAged 80 and overAPACHE IIbusiness.industryKidney Tubular Necrosis AcuteMiddle AgedSurgerycritical careacute tubular necrosisSAPS IINephrologyPredictive value of testsFemaleHemodialysisprognosisbusinessKidney International
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Predicción de riesgo de rechazo agudo en pacientes con trasplante renal

2009

Objective: Create a model to predict the risk of acute rejection of kidney transplant considering variables related to the immunosuppressant agent used, the receiver, the donor and the transplanted organ. Methods: Cohort study in a population of 68 patients with kidney transplants being treated with tacrolimus triple therapy. Predicting the risk of acute rejection was carried out with a logistic regression analysis using age, sex, re-transplant status, number of HLA incompatibilities, cold ischaemia time, acute tubular necrosis, induction with basiliximab or thymoglobulin and treatment type as explanatory variables. The contribution of variables associated with determining the blood concent…

PharmacologyKidneymedicine.medical_specialtyeducation.field_of_studyThymoglobulinBasiliximabbusiness.industryPopulationmedicine.diseaseLogistic regressionGastroenterologyTacrolimusmedicine.anatomical_structureInternal medicinemedicineeducationbusinessAcute tubular necrosismedicine.drugCohort studyFarmacia Hospitalaria
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Increased Hospital Stay and Allograft Disfunction in Renal Transplant Recipients with Cyp2c19 AA Variant in SNP rs4244285

2012

Pharmacogenetics correlates certain genetic variants, such as single nucleotide polymorphisms (SNPs), with blood drug levels, efficacy, and adverse effects of the treatment. Tacrolimus is mainly metabolized via CYP3A4/5, whereas CYP2C19 and CYP3A4/5 are responsible for omeprazole metabolism. Omeprazole inhibits tacrolimus metabolism via CYP3A5 in patients carrying variant alleles of CYP2C19, increasing tacrolimus blood concentrations. Seventy-five renal transplant recipients treated with tacrolimus and concomitant omeprazole were genotyped in a panel of 37 SNPs with use of Sequenom MassArray. The patients with CYP2C19*2/*2 genotype (n = 4) showed a median posttransplantation hospital stay o…

Pharmacologymedicine.medical_specialtybusiness.industryPharmaceutical ScienceCYP2C19Pharmacologymedicine.diseaseGastroenterologyTacrolimusTransplantationsurgical procedures operativeBlood drugInternal medicinemedicineAdverse effectbusinessOmeprazolePharmacogeneticsAcute tubular necrosismedicine.drugDrug Metabolism and Disposition
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Predicting risk of acute rejection in patients with kidney transplants

2009

Objective: Create a model to predict the risk of acute rejection of kidney transplant considering variables related to the immunosuppressant agent used, the receiver, the donor, and the transplanted organ. Methods: Cohort study in a population of 68 patients with kidney transplants being treated with tacrolimus triple therapy. Predicting the risk of acute rejection was carried out with a logistic regression analysis using age, sex, retransplant status, number of HLA incompatibilities, cold ischaemia time, acute tubular necrosis, induction with basiliximab or thymoglobulin, and treatment type as explanatory variables. The contribution of variables associated with determining the blood concen…

medicine.medical_specialtyeducation.field_of_studyThymoglobulinBasiliximabbusiness.industryPopulationmedicine.diseaseLogistic regressionGastroenterologyTacrolimusSurgeryInternal medicinemedicineeducationbusinessKidney transplantationAcute tubular necrosismedicine.drugCohort studyFarmacia Hospitalaria (English Edition)
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